Tumor-associated embryonic antigen-expressing vaccines that target CCR6 elicit potent CD8+ T cell-mediated protective and therapeutic antitumor immunity
A Biragyn, R Schiavo, P Olkhanud… - The Journal of …, 2007 - journals.aai.org
Despite its potency, the wider use of immunotherapy for B cell malignancies is hampered by
the lack of well-defined tumor-specific Ags. In this study, we demonstrate that an
evolutionarily conserved 37-kDa immature laminin receptor protein (OFA-iLRP), a
nonimmunogenic embryonic Ag expressed by a variety of tumors, is rendered immunogenic
if targeted to the APCs using the CCR6 ligands MIP3α/CCL20 and mDF2β. The CCR6
targeting facilitated efficient Ag cross-presentation and induction of tumor-neutralizing CTLs …
the lack of well-defined tumor-specific Ags. In this study, we demonstrate that an
evolutionarily conserved 37-kDa immature laminin receptor protein (OFA-iLRP), a
nonimmunogenic embryonic Ag expressed by a variety of tumors, is rendered immunogenic
if targeted to the APCs using the CCR6 ligands MIP3α/CCL20 and mDF2β. The CCR6
targeting facilitated efficient Ag cross-presentation and induction of tumor-neutralizing CTLs …
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